3Rs - search page

There are several stages to consider when planning and carrying out studies involving animals to establish, implement and refine humane endpoints.

A group of passionate enrichment advocates from academia and industry are the spark for this effort to ignite and excite the laboratory animal community from top to bottom. 

The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments) - have been published in the Journal of Cerebral Blood Flow and Metabolism

The goal of this project was to develop and implement a harmonized guideline for ideal and maximum dose volumes for various routes for the most common laboratory animals in biomedical research. 

These reccomendations are provided by Deutsche Forschungsgemeinschaft  and are available in English. They may apply for a Three R information retrieval and the way, the retrieved information is processed and discussed in the project applications (to safeguard transparency, etc.).  

The Macaque Website is a free resource for everyone who works with, or is interested in, laboratory macaques: animal care staff and technicians, facility managers, veterinarians, researchers, students, policy makers and IACUC/AWERB members. Developed by the UK’s National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), this site provides referenced information and practical guidance on the natural history and behaviour of macaques, their care and management in captivity, and ways to assess their welfare.

Procedures with Care Website by Newcastle University, NC3Rs and IAT, provides a series of resources to support the adoption of best practice for commonly used procedures in animal research. The focus is on rats and mice but further material will be added to expand the range of techniques and species in the future.   

ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are intended to improve the reporting of research using animals – maximising information published and minimising unnecessary studies.

The use of animals in medical and pharmaceutical research is essential to the understanding of disease and the safe development of medicines.

The CAMARADES collaboration provides a supporting framework for groups involved in the systematic review and meta-analysis of data from experimental animal studies. 

Our interests range from identifying potential sources of bias in animal work; developing recommendations for improvements in the design and reporting of animal studies; developing the meta-analysis methodology the better to apply it to animal studies; through to the selection of candidate stroke drugs for clinical trial. 

CAMARADES aims to provide a central focus for data sharing; to act as a resource for those wishing to carry out such reviews; to provide a web based stratified meta-analysis bioinformatics engine (under development!); and to act as a repository for completed reviews.

Consensus meetings on the care and use of fish, wildlife and agricultural animals in research is provided by Norecopa. It contains presentations, guidelines and consensus statements from four international meetings covering all Three Rs, is in English and free of charge.

Produced by Norecopa containing sort films, which alternatively can be viewed as slide series, illustrating common techniques. It is in English and free of charge.