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University Biomedical Services (UBS)

 

3Rs

Pain and Laboratory Animals: Publication Practices for Better Data Reproducibility and Better Animal Welfare
Topic: Refinement

RSPCA Reduce Suffering Welfare Assessment

The term ‘welfare assessment’ refers to monitoring animals for signs of pain, suffering and distress associated with procedures and their effects, as well as to the day-to-day assessment of all animals to see how they are coping with their environment and to detect health or welfare issues. Indicators of positive wellbeing, such as appropriate levels of grooming and social interaction, should also be included when devising welfare assessment protocols.

Topic: Refinement

Ex Vivo Culture Platform for Assessment of Cartilage Repair Treatment Strategies

There is a great need for valuable ex vivo models that allow for assessment of cartilage repair strategies to reduce the high number of animal experiments.

Topic: Reduction

Refinement of Blood Sampling-NC3Rs

Blood sampling can be stressful for laboratory animals because of the handling, restraint, anaesthesia or discomfort associated with a particular technique

Topic: Refinement

General Database Information

Global List of Guidelines

The website is maintained by Norecopa. It covers all Three Rs, is in English and free of charge.  

Topic: Other Resources

Guidelines On the Care and Use of Fish in Research

The website is maintained by Norecopa. It covers all Three Rs, is in English and free of charge.  

Topic: Other Resources

Guidelines for "Good Scientific Practice"

These reccomendations are provided by Deutsche Forschungsgemeinschaft  and are available in English. They may apply for a Three R information retrieval and the way, the retrieved information is processed and discussed in the project applications (to safeguard transparency, etc.).  

Topic: Other Resources

The Macaque Website

The Macaque Website is a free resource for everyone who works with, or is interested in, laboratory macaques: animal care staff and technicians, facility managers, veterinarians, researchers, students, policy makers and IACUC/AWERB members. Developed by the UK’s National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), this site provides referenced information and practical guidance on the natural history and behaviour of macaques, their care and management in captivity, and ways to assess their welfare.

Topic: Other Resources

Procedures With Care

Procedures with Care Website by Newcastle University, NC3Rs and IAT, provides a series of resources to support the adoption of best practice for commonly used procedures in animal research. The focus is on rats and mice but further material will be added to expand the range of techniques and species in the future.   

Topic: Other Resources

ARRIVE Guidelines

ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are intended to improve the reporting of research using animals – maximising information published and minimising unnecessary studies.

Topic: Other Resources

Use of Animals in Pharmaceutical Research

The use of animals in medical and pharmaceutical research is essential to the understanding of disease and the safe development of medicines.

Topic: Other Resources

CAMARADES

The CAMARADES collaboration provides a supporting framework for groups involved in the systematic review and meta-analysis of data from experimental animal studies. 

Our interests range from identifying potential sources of bias in animal work; developing recommendations for improvements in the design and reporting of animal studies; developing the meta-analysis methodology the better to apply it to animal studies; through to the selection of candidate stroke drugs for clinical trial. 

CAMARADES aims to provide a central focus for data sharing; to act as a resource for those wishing to carry out such reviews; to provide a web based stratified meta-analysis bioinformatics engine (under development!); and to act as a repository for completed reviews.

Topic: Other Resources

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