3Rs - search page

Systematic reviews: Evidence from animal research is considered by researchers to be of the lowest quality in medical research.

There is a great need for valuable ex vivo models that allow for assessment of cartilage repair strategies to reduce the high number of animal experiments.

Designed to facilitate sharing-SEARCH and SEARCHBreast provide scientists with choices when determining the most robust and relevant models to use when studying human disease.

‘Research integrity’ is an overarching term relating to the standards to which research is done. It requires every individual to acknowledge their responsibilities as well as being accountable for adhering to legal and ethical principles. 

A mainly government funded body which provides input to the UK’s Three Rs agenda, carries out research and provides funds for Three R research. 

The Macaque Website is a free resource for everyone who works with, or is interested in, laboratory macaques: animal care staff and technicians, facility managers, veterinarians, researchers, students, policy makers and IACUC/AWERB members. Developed by the UK’s National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), this site provides referenced information and practical guidance on the natural history and behaviour of macaques, their care and management in captivity, and ways to assess their welfare.

TSAR is a tool aimed at providing a transparent view on the status of alternative methods as they progress from purely scientific protocols submitted for eventual validation to being actively used in a regulatory context. This tracking system intends to cover all steps, from the initial submission for validation until final adoption by inclusion in the EU legislation and/or related Guidance Documents, when appropriate.   

Procedures with Care Website by Newcastle University, NC3Rs and IAT, provides a series of resources to support the adoption of best practice for commonly used procedures in animal research. The focus is on rats and mice but further material will be added to expand the range of techniques and species in the future.   

ICLAS is an international scientific organization dedicated to advancing human and animal health by promoting the ethical  care and use of laboratory animals in research worldwide.

ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are intended to improve the reporting of research using animals – maximising information published and minimising unnecessary studies.

The Animal Welfare Information Center (AWIC) is is part of the US Department of Agriculture. It is mandated by the Animal Welfare Act (AWA) to provide information for improved animal care and use in research, testing, teaching, and exhibition.