3Rs - search page

Systematic reviews: Evidence from animal research is considered by researchers to be of the lowest quality in medical research.

There is a great need for valuable ex vivo models that allow for assessment of cartilage repair strategies to reduce the high number of animal experiments.

Designed to facilitate sharing-SEARCH and SEARCHBreast provide scientists with choices when determining the most robust and relevant models to use when studying human disease.

‘Research integrity’ is an overarching term relating to the standards to which research is done. It requires every individual to acknowledge their responsibilities as well as being accountable for adhering to legal and ethical principles. 

The website is maintained by Norecopa. It covers all Three Rs, is in English and free of charge.  

These reccomendations are provided by Deutsche Forschungsgemeinschaft  and are available in English. They may apply for a Three R information retrieval and the way, the retrieved information is processed and discussed in the project applications (to safeguard transparency, etc.).  

The Macaque Website is a free resource for everyone who works with, or is interested in, laboratory macaques: animal care staff and technicians, facility managers, veterinarians, researchers, students, policy makers and IACUC/AWERB members. Developed by the UK’s National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), this site provides referenced information and practical guidance on the natural history and behaviour of macaques, their care and management in captivity, and ways to assess their welfare.

Procedures with Care Website by Newcastle University, NC3Rs and IAT, provides a series of resources to support the adoption of best practice for commonly used procedures in animal research. The focus is on rats and mice but further material will be added to expand the range of techniques and species in the future.   

ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are intended to improve the reporting of research using animals – maximising information published and minimising unnecessary studies.

The CAMARADES collaboration provides a supporting framework for groups involved in the systematic review and meta-analysis of data from experimental animal studies. 

Our interests range from identifying potential sources of bias in animal work; developing recommendations for improvements in the design and reporting of animal studies; developing the meta-analysis methodology the better to apply it to animal studies; through to the selection of candidate stroke drugs for clinical trial. 

CAMARADES aims to provide a central focus for data sharing; to act as a resource for those wishing to carry out such reviews; to provide a web based stratified meta-analysis bioinformatics engine (under development!); and to act as a repository for completed reviews.

Consensus meetings on the care and use of fish, wildlife and agricultural animals in research is provided by Norecopa. It contains presentations, guidelines and consensus statements from four international meetings covering all Three Rs, is in English and free of charge.