FRAME is dedicated to the development of new and valid methods that will replace the need for laboratory animals in medical and scientific research, education, and testing. Where the use of animals is currently necessary, FRAME supports the reduction of numbers involved to an unavoidable minimum and refinement of experimental procedures to minimise any suffering caused. The E-learning resource of FRAME has been set up to provide teachers, school children, students and general supporters with information about the different areas of animal experimentation and with specific resources as to how it can be reduced, refined or replaced.
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General Database Information
Fund for the Replacement of Animals in Medical Experiments (FRAME)
Topic: Portals and Websites
Global List of Guidelines
The website is maintained by Norecopa. It covers all Three Rs, is in English and free of charge.
Topic: Other Resources
American Association for Laboratory Animal Science (AALAS)
AALAS is an association of professionals that advances responsible laboratory animal care and use to benefit people and animals.
Topic: "Three Rs"
Humane Endpoints Website
Humane Endpoints Website is provided by 3Rs-Centre Utrecht Life Sciences, gives insight into the recognition and application of humane endpoints in rodents. The website contributes to refinement, the prevention of unnecessary suffering in laboratory animals, by offering information, videos and photographs of rodent species. In addition, the website provides free training modules (accessible after registration). The site is currently available in EN, NL and FR. DE and ES will follow soon.
Topic: Portals and Websites
RSPCA- 3Rs and Vaccine Testing
Vaccination of animals against disease protects them from suffering. However, this comes with an animal welfare cost - the safety and efficacy of vaccines is assessed in experimental animals and the tests involved can cause significant pain and distress. There is an ethical dilemma in protecting one set of animals at the expense of others but implementation of the 3Rs can help to resolve this. The research animals department works with researchers involved in vaccine testing and regulators to promote the 3Rs in this important area.
Topic: "Three Rs"
Guidelines On the Care and Use of Fish in Research
The website is maintained by Norecopa. It covers all Three Rs, is in English and free of charge.
Topic: Other Resources
Species specific
Felasa Guidance For The Care and Welfare of Cephalopods in Research
Topic: Cephalopod
Cephalopods in Neuroscience: Regulations, Research and the 3Rs
Topic: Cephalopod
Guidelines for the Care and Welfare of Cephalopods in Research
A consensus based on an initiative by CephRes, FELASA and the Boyd Group.
Topic: Cephalopod
Guidance on Cephalopods
Topic: Cephalopod