3Rs - search page

The goal of this project was to develop and implement a harmonized guideline for ideal and maximum dose volumes for various routes for the most common laboratory animals in biomedical research. 

Our ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are intended to improve the reporting of research using animals – maximising information published and minimising unnecessary studies.

The I3R group produced the first edition of this document in January 2001 to assist researches and information professionals in the pharmaceutical industry.  

This site provides an interactive short course on experimental design for research scientists working with laboratory animals. The aim is to reduce the number of animals which are used, improve the quality of the science and save time, money and other scientific resources.

CAMARADES provides a supporting framework for groups involved in the systematic review and meta-analysis of data.

CCAC promotes the application of Three Rs in Canada. Through a website it provides the latest information on the Three Rs,   a search tool and a search guide. 

FRAME is dedicated to the development of new and valid methods that will replace the need for laboratory animals in medical and scientific research, education, and testing. Where the use of animals is currently necessary, FRAME supports the reduction of numbers involved to an unavoidable minimum and refinement of experimental procedures to minimise any suffering caused. The E-learning resource of FRAME has been set up to provide teachers, school children, students and general supporters with information about the different areas of animal experimentation and with specific resources as to how it can be reduced, refined or replaced. 

Humane Endpoints Website is provided by 3Rs-Centre Utrecht Life Sciences, gives insight into the recognition and application of humane endpoints in rodents. The website contributes to refinement, the prevention of unnecessary suffering in laboratory animals, by offering information, videos and photographs of rodent species. In addition, the website provides free training modules (accessible after registration). The site is currently available in EN, NL and FR. DE and ES will follow soon.