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Appendix A of the Animal Usage Form asks for the methods used to search for alternatives to procedures that may cause more than slight pain or distress to animals.

LAS Interactive brings together the free information portal vtk online and the training portal las campus. The website adresses researchers, students, competent authorities, trainers as well as technical staff at Universities, independent research facilities and the industry.

Bibliography on Alternatives to Animal Testing (Altbib), is a resource portal for Alternatives to the Use of Live Vertebrates in Biomedical Research and Testing hosted by Specialized Information Services of US National Library of Medicine.

CAAT is an academic, science based centre within the John Hopkins Bloomberg School of Public Health in the USA and the University of Konstanz in Germany which is  dedicated to the promotion of research intoin vitro and other alternative techniques, Three Rs education and information.

Modern human-relevant technology has the potential to provide answers traditionally sought through animal research. Yet in many of these areas there is little momentum to transition away from animal use. Education is a key driver that helps increase the impetus for change.

Replacing Animal Research believes that a whole system approach to replacing animals in research is the best way to facilitate change and ensure the development and uptake of human-relevant research methods. This system is driven by the work and choices made by various stakeholders including funders, journal editors, regulators, industry, academics, legislators, and of course scientists. Relevant training and awareness of the current research landscape are important in these roles to help inform valid scientific and ethical choices, and help prioritise non-animal research.. Through education it is possible to share information about the system, develop confidence in the use of alternative methods, and challenge the use of animals in different areas of research and testing.

CCAC promotes the application of Three Rs in Canada. Through a website it provides the latest information on the Three Rs,   a search tool and a search guide. 

Humane Endpoints Website is provided by 3Rs-Centre Utrecht Life Sciences, gives insight into the recognition and application of humane endpoints in rodents. The website contributes to refinement, the prevention of unnecessary suffering in laboratory animals, by offering information, videos and photographs of rodent species. In addition, the website provides free training modules (accessible after registration). The site is currently available in EN, NL and FR. DE and ES will follow soon.

The Canadian Centre for Alternatives to Animal Methods (CCAAM) and the Canadian Centre for the Validation of Alternative Methods (CaCVAM) aim to develop, validate, and promote non-animal, human biology-based platforms in biomedical research, education, and chemical safety testing.