3Rs - search page

Humane Endpoints Website is provided by 3Rs-Centre Utrecht Life Sciences, gives insight into the recognition and application of humane endpoints in rodents. The website contributes to refinement, the prevention of unnecessary suffering in laboratory animals, by offering information, videos and photographs of rodent species. In addition, the website provides free training modules (accessible after registration). The site is currently available in EN, NL and FR. DE and ES will follow soon.

EU 3Rs databases-The protection and welfare of animals is an area covered by a wide range of EU legislation. This includes the protection of wildlife, zoo animals, farm animals, animals in transport and animals used for scientific purposes. Animal studies, whether for the development or production of new medicines, for physiological studies, for studying environmental effects or for the testing of chemicals or new food additives, has to be carried out in compliance with EU legislation. 

Three Rs Resources

The Australian and New Zealand Council for the Care of Animals in Research and Teaching (ANZCCART) and the Ministry for Primary Industries have produced a series of booklets on the application of the three Rs (replacement, reduction and refinement) in the use of animals in research and teaching.

• Cell-based Disease Models (replacement)
• Computer Assisted Learning (replacement)
• Mannequins and Dummies (replacement)
• Alternatives to shellfish toxicity testing (replacement) 
• Fireflies to the rescue (reduction)
• Mathematical models (reduction)
• Tissue sharing (reduction)
• Simple ingenuity (refinement)
• Non-Invasive Methods (refinement)
• Living syringes (refinement)
• Oil emulsified gels (refinement)

This section of the Three Rs microsite provides useful links and information to help visitors easily find a wide range of resources.

The aim of "InVitroJobs" is to enable researchers to access this branch of research more easily. Alongside the job search portal, the site maintains an up-to-date list of research groups active in the development of animal-free techniques. The primary aims of this list are to advertise job vacancies, to provide students with the opportunity to contact these research groups directly to obtain information for thesis assignments and to promote cooperation, networking and the exchange of ideas between researchers. 

 Find Human tissue samples online using the UKCRC Tissue Directory.

The Allen Brain Observatory presents the first standardized in vivo survey of physiological activity in the mouse visual cortex, featuring representations of visually evoked calcium responses from GCaMP6-expressing neurons in selected cortical layers, visual areas and Cre lines. 

A mainly government funded body which provides input to the UK’s Three Rs agenda, carries out research and provides funds for Three R research. 

By generating and making public data that indicates how cells respond to various genetic and environmental stressors, the LINCS project will help us gain a more detailed understanding of cell pathways and aid efforts to develop therapies.