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General Database Information
EU 3Rs databases-The protection and welfare of animals is an area covered by a wide range of EU legislation. This includes the protection of wildlife, zoo animals, farm animals, animals in transport and animals used for scientific purposes. Animal studies, whether for the development or production of new medicines, for physiological studies, for studying environmental effects or for the testing of chemicals or new food additives, has to be carried out in compliance with EU legislation.
Three Rs Resources
The Australian and New Zealand Council for the Care of Animals in Research and Teaching (ANZCCART) and the Ministry for Primary Industries have produced a series of booklets on the application of the three Rs (replacement, reduction and refinement) in the use of animals in research and teaching.
- Cell-based Disease Models (replacement)
- Computer Assisted Learning (replacement)
- Mannequins and Dummies (replacement)
- Alternatives to shellfish toxicity testing (replacement)
- Fireflies to the rescue (reduction)
- Mathematical models (reduction)
- Tissue sharing (reduction)
- Simple ingenuity (refinement)
- Non-Invasive Methods (refinement)
- Living syringes (refinement)
- Oil emulsified gels (refinement)
The use of animals in medical and pharmaceutical research is essential to the understanding of disease and the safe development of medicines.
This section of the Three Rs microsite provides useful links and information to help visitors easily find a wide range of resources.
Find Human tissue samples online using the UKCRC Tissue Directory.
The Allen Brain Observatory presents the first standardized in vivo survey of physiological activity in the mouse visual cortex, featuring representations of visually evoked calcium responses from GCaMP6-expressing neurons in selected cortical layers, visual areas and Cre lines.
The CAMARADES collaboration provides a supporting framework for groups involved in the systematic review and meta-analysis of data from experimental animal studies.
Our interests range from identifying potential sources of bias in animal work; developing recommendations for improvements in the design and reporting of animal studies; developing the meta-analysis methodology the better to apply it to animal studies; through to the selection of candidate stroke drugs for clinical trial.
CAMARADES aims to provide a central focus for data sharing; to act as a resource for those wishing to carry out such reviews; to provide a web based stratified meta-analysis bioinformatics engine (under development!); and to act as a repository for completed reviews.
By generating and making public data that indicates how cells respond to various genetic and environmental stressors, the LINCS project will help us gain a more detailed understanding of cell pathways and aid efforts to develop therapies.
INFRAFRONTIER is the European Research Infrastructure for phenotyping and archiving of model mammalian genomes. The INFRAFRONTIER Research Infrastructure provides access to first-class tools and data for biomedical research, and thereby contributes to improving the understanding of gene function in human health and disease using the mouse model.