Isogenic strains (inbred strains and F1 hybrids) are like immortal clones of genetically identical individuals. The same genotype can be reproduced indefinitely. They have already made a substantial contribution to biomedical research.
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3Rs
Reducing Mouse Numbers by Measuring Tumour Size Non-Invasively
Scientists at the ICR are increasingly using non-invasive methods to measure the size of tumours in mice – allowing the same mouse to be assessed several times and reducing the overall numbers
Topic: Reduction
SABRE Research UK
Systematic reviews: Evidence from animal research is considered by researchers to be of the lowest quality in medical research.
Topic: Reduction
Ex Vivo Culture Platform for Assessment of Cartilage Repair Treatment Strategies
There is a great need for valuable ex vivo models that allow for assessment of cartilage repair strategies to reduce the high number of animal experiments.
Topic: Reduction
New Tools for The Generation of peptide- and Antibody-Based Ligands in Vitro: Reduction of Antibody Production in Experimental Animals
Topic: Reduction
Discipline tool
Bernstein Center for Computational Neuroscience Göttingen
The Bernstein Center for Computational Neuroscience (BCCN) Goettingen aims at finding the cooperative dynamics and adaptivity in neuronal systems.
Topic: Neurology
Stem Cell Research- Diabetes Research
Topic: Diabetes
IMPROVE-Stroke Research
Over the last two years, representatives from the UK’s stroke research community have been working, in a collaboration led by the NC3Rs, to improve the welfare and increase the scientific value of rodent models of stroke.
Topic: Neurology