3Rs - search page

CELPHEDIA (Creation, Breeding, Phenotyping, Distribution and Archiving of model organisms) is a national operational research infrastructure distributed over the French territory. Its mission is to support academic and industrial scientific community to accelerate discoveries in biology and improve biomedical research.

In collaboration with the Animal Welfare Information Center at the US Department of Agriculture in Beltsville, USA has produced a database which provides an overview of guidelines, databases, journals, email lists, regulations and policies which may help researchers to implement the 3Rs when planning research that may involve animals. The database is called 3R Guide.

The aim of 3R Guide is to provide a 'one-stop shop' for researchers who need to gain an overview of available 3R resources.

Toxicology Data Network- is a group of databases covering chemicals and drugs, diseases and the environment, environmental health, occupational safety and health, poisoning, risk assessment and regulations, and toxicology.

Three Rs Resources

The Australian and New Zealand Council for the Care of Animals in Research and Teaching (ANZCCART) and the Ministry for Primary Industries have produced a series of booklets on the application of the three Rs (replacement, reduction and refinement) in the use of animals in research and teaching.

• Cell-based Disease Models (replacement)
• Computer Assisted Learning (replacement)
• Mannequins and Dummies (replacement)
• Alternatives to shellfish toxicity testing (replacement) 
• Fireflies to the rescue (reduction)
• Mathematical models (reduction)
• Tissue sharing (reduction)
• Simple ingenuity (refinement)
• Non-Invasive Methods (refinement)
• Living syringes (refinement)
• Oil emulsified gels (refinement)

Researchers can apply for access to data from health registries and health studies, as well as biological material from the biobanks. Here you will find guidelines and electronic application forms.

NORINA is an English-language database containing information on over 3,500 audiovisual aids that may be used as alternatives or supplements to the use of animals in education and training, including dissection alternatives, at all levels from Junior School to University.  The information in the database has been collected from 1991 onwards.

Embase is a crucial resource for discovering biomedical evidence within published, peer-reviewed literature, in-press publications and conference abstracts.

NorPEN is a network of researchers with the purpose of facilitating research within the field of pharmacoepidemiology in the Nordic countries. The website