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The use of animals in research, teaching and testing is an important ethical and political issue. Much of the discussion about this issue revolves around the relative value, often referred to as 'moral value', of humans and animals.

The International Society for Pharmacoepidemiology (ISPE) is a non-profit international professional membership organization dedicated to advancing the health of the public by providing a forum for the open exchange of scientific information and for the development of policy; education; and advocacy for the field of pharmacoepidemiology, including pharmacovigilance, drug utilization research, outcomes research, comparative effectiveness research, and therapeutic risk management.

In collaboration with the Animal Welfare Information Center at the US Department of Agriculture in Beltsville, USA has produced a database which provides an overview of guidelines, databases, journals, email lists, regulations and policies which may help researchers to implement the 3Rs when planning research that may involve animals. The database is called 3R Guide.

The aim of 3R Guide is to provide a 'one-stop shop' for researchers who need to gain an overview of available 3R resources.

Over the past twenty years or so, there has been a ‘revolution’ in the life sciences,and our knowledge and capabilities have dramatically increased. At the same time, these advances have raised very important ethical concerns in both the scientific community and with the public at large.

CELPHEDIA (Creation, Breeding, Phenotyping, Distribution and Archiving of model organisms) is a national operational research infrastructure distributed over the French territory. Its mission is to support academic and industrial scientific community to accelerate discoveries in biology and improve biomedical research.

A special report can be found on this page titled: Utility and Morality:Contemporary Tradeoffs. Within this report there is an article by Bernard E. Rollin titled The Moral Status of Invasive Animal Research.

NORINA is an English-language database containing information on over 3,500 audiovisual aids that may be used as alternatives or supplements to the use of animals in education and training, including dissection alternatives, at all levels from Junior School to University.  The information in the database has been collected from 1991 onwards.

The Academy is working to address all aspects of animals in research, from engaging in debate about how to regulate the use of animals in research, to efforts to improve the openness of organisations that are involved in animal research.

Toxicology Data Network- is a group of databases covering chemicals and drugs, diseases and the environment, environmental health, occupational safety and health, poisoning, risk assessment and regulations, and toxicology.