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Appendix A of the Animal Usage Form asks for the methods used to search for alternatives to procedures that may cause more than slight pain or distress to animals.

To establish international cooperation in the critical areas of validation studies, independent peer review, and development of harmonized recommendations in order to ensure worldwide acceptance.

The Alternative Test Methods Table is a resource for investigators and regulators on the validation and regulatory status of alternatives to animal-based regulatory test methods.

The RSPCA list a number of Alternative approaches: the use of isolated cells and tissues, using computers and mathematics to model biological processes and predict the effects of chemicals and drugs, designing ways of doing experiments safely in human volunteers, using simple organisms, such as bacteria, to study basic biological processes
exploring new advanced technologies such as robotics, molecular techniques, tissue engineering and "organs-on-microchips", not doing the experiment at all is one option - we encourage greater consideration of whether animal use could be avoided through more critical ethical review.

World leader in innovations without laboratory animals by 2025. That is the aim of the Dutch Minister for Agriculture, Martijn van Dam. In March 2016, the Minister asked the Netherlands National Committee for the protection of animals used for scientific purposes (NCad) to draw up a schedule for the phasing out of animal procedures.

Internet platform for animal free research (German site).

Below are articles on the subject of Alternatives. If you can't see what you are looking for other categories are displayed on the left under 'Our Quick Links'.

The PETA International Science Consortium Ltd. promotes non-animal research methods and coordinates the scientific and regulatory expertise of its members. With an eye toward championing the best non-animal methods and replacing tests on animals, the Science Consortium brings scientific expertise and extensive knowledge of the international regulatory environment to the development of testing protocols.

ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are intended to improve the reporting of research using animals – maximising information published and minimising unnecessary studies.

The CAMARADES collaboration provides a supporting framework for groups involved in the systematic review and meta-analysis of data from experimental animal studies. 

Our interests range from identifying potential sources of bias in animal work; developing recommendations for improvements in the design and reporting of animal studies; developing the meta-analysis methodology the better to apply it to animal studies; through to the selection of candidate stroke drugs for clinical trial. 

CAMARADES aims to provide a central focus for data sharing; to act as a resource for those wishing to carry out such reviews; to provide a web based stratified meta-analysis bioinformatics engine (under development!); and to act as a repository for completed reviews.

Consensus meetings on the care and use of fish, wildlife and agricultural animals in research is provided by Norecopa. It contains presentations, guidelines and consensus statements from four international meetings covering all Three Rs, is in English and free of charge.

Produced by Norecopa containing sort films, which alternatively can be viewed as slide series, illustrating common techniques. It is in English and free of charge.