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Appendix A of the Animal Usage Form asks for the methods used to search for alternatives to procedures that may cause more than slight pain or distress to animals.

To establish international cooperation in the critical areas of validation studies, independent peer review, and development of harmonized recommendations in order to ensure worldwide acceptance.

The Alternative Test Methods Table is a resource for investigators and regulators on the validation and regulatory status of alternatives to animal-based regulatory test methods.

The RSPCA list a number of Alternative approaches: the use of isolated cells and tissues, using computers and mathematics to model biological processes and predict the effects of chemicals and drugs, designing ways of doing experiments safely in human volunteers, using simple organisms, such as bacteria, to study basic biological processes
exploring new advanced technologies such as robotics, molecular techniques, tissue engineering and "organs-on-microchips", not doing the experiment at all is one option - we encourage greater consideration of whether animal use could be avoided through more critical ethical review.

World leader in innovations without laboratory animals by 2025. That is the aim of the Dutch Minister for Agriculture, Martijn van Dam. In March 2016, the Minister asked the Netherlands National Committee for the protection of animals used for scientific purposes (NCad) to draw up a schedule for the phasing out of animal procedures.

Internet platform for animal free research (German site).

Below are articles on the subject of Alternatives. If you can't see what you are looking for other categories are displayed on the left under 'Our Quick Links'.

The PETA International Science Consortium Ltd. promotes non-animal research methods and coordinates the scientific and regulatory expertise of its members. With an eye toward championing the best non-animal methods and replacing tests on animals, the Science Consortium brings scientific expertise and extensive knowledge of the international regulatory environment to the development of testing protocols.

Journal of Applied Animal Welfare Science (JAAWS) is a US journal that publishes articles, commentaries, and brief research reports on methods of experimentation, husbandry and care that demonstrably enhance the welfare of all nonhuman animals.

The official journal of the Institute of Animal Technology and of the European Federation of Animal Technologists (EFAT).Animal Technology and Welfare aims to be the medium for animal technologists and all those concerned with the care and welfare of animals used for research purposes to communicate ‘best practice. ATW especially aims to promote and develop the 3Rs particularly in respect of Refinement.

More importantly, ATW promotes the generally accepted ‘4th R’, Responsibility. The responsibility that all animal technologists have in ensuring dissemination of ‘best practice’ to every institution using animals in research. ATW enjoys a unique position as the scientific publication for the leading organisations (IAT and EFAT) for the welfare of animals in research.

ATLA is published by  FRAME, and has been a key scientific journal in the field of laboratory animal alternatives for more than 30 years. Circulated worldwide, ATLA is distributed to individuals, organisations and institutions. It covers the  latest research relating to alternatives to the use of laboratory animals.

ALTEX publishes original articles, short communications, and reviews, as well as news and comments, meeting reports, and book reviews. Animal experiments are defined by the editors as all experimental procedures involving the use of animals in testing, research, and education, or to obtain tissues, organs, and other animal derived products that may cause pain or distress to animals..