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3Rs

Recommended Dose Volumes for Common Laboratory Animals

The goal of this project was to develop and implement a harmonized guideline for ideal and maximum dose volumes for various routes for the most common laboratory animals in biomedical research. 

Topic: Reduction

ARRIVE (Animal Research: Reporting of In Vivo Experiments) Guidelines

Our ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are intended to improve the reporting of research using animals – maximising information published and minimising unnecessary studies.

Topic: Reduction

Searching for 3Rs Information - Published Literature Sources

The I3R group produced the first edition of this document in January 2001 to assist researches and information professionals in the pharmaceutical industry.  

Topic: Reduction

3Rs Reduction

This site provides an interactive short course on experimental design for research scientists working with laboratory animals. The aim is to reduce the number of animals which are used, improve the quality of the science and save time, money and other scientific resources.

Topic: Reduction

Collaborative Approach to Metanalysis

CAMARADES provides a supporting framework for groups involved in the systematic review and meta-analysis of data.

Topic: Reduction

General Database Information

Dutch 3Rs Centre- Utrecht Life Sciences
Topic: "Three Rs"

US Food and Drug Administration (USFDA)
Topic: Information on drugs and diseases

The Nordic Pharmaco Epidemiological Network (NorPEN)

NorPEN is a network of researchers with the purpose of facilitating research within the field of pharmacoepidemiology in the Nordic countries. The website

Topic: Information on drugs and diseases

European Consensus Platform for Alternatives (ECOPA)
Topic: "Three Rs"

Animal Research Info

Animal Research Info-is an international collaboration of scientists and researchers. As expert contributors, we provide and edit the content, making it as accurate and up-to-date as possible.

Topic: Information on drugs and diseases

WHO Collaborating Centre for International Drug Monitoring (UMC)

UMC regularly publishes scientific papers in a range of international journals. These papers record progress and results from research into clinical or methodological issues in pharmacovigilance.

Topic: Information on drugs and diseases

The Federation of Laboratory Animal Science Associations (FELASA)
Topic: "Three Rs"

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