3Rs - search page

"The Design of Animal Experiments" is intended for all research scientists who use laboratory animals, with the aim of helping them to design their own experiments more effectively.

Isogenic strains (inbred strains and F1 hybrids) are like immortal clones of genetically identical individuals. The same genotype can be reproduced indefinitely. They have already made a substantial contribution to biomedical research. 

Scientists at the ICR are increasingly using non-invasive methods to measure the size of tumours in mice – allowing the same mouse to be assessed several times and reducing the overall numbers

Systematic reviews: Evidence from animal research is considered by researchers to be of the lowest quality in medical research.

There is a great need for valuable ex vivo models that allow for assessment of cartilage repair strategies to reduce the high number of animal experiments.

Over the last two years, representatives from the UK’s stroke research community have been working, in a collaboration led by the NC3Rs, to improve the welfare and increase the scientific value of rodent models of stroke. The findings from the collaboration - The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)  have been published in the Journal of Cerebral Bloodflow and Metabolism.