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FRAME is dedicated to the development of new and valid methods that will replace the need for laboratory animals in medical and scientific research, education, and testing. Where the use of animals is currently necessary, FRAME supports the reduction of numbers involved to an unavoidable minimum and refinement of experimental procedures to minimise any suffering caused. The E-learning resource of FRAME has been set up to provide teachers, school children, students and general supporters with information about the different areas of animal experimentation and with specific resources as to how it can be reduced, refined or replaced. 

This gateway provides a place for researchers funded by the NC3Rs to promote the 3Rs impact of their work, and publish rapidly, in an open and transparent manner.

The Sanger Mouse Genetics Programme (Sanger MGP) was initiated in 2006 to advance the functional understanding of protein coding and non-coding RNA genes using a standardised high-throughput phenotypic screen designed to contribute to improved diagnosis and treatment of human disease.

INFRAFRONTIER aims to build a world-class research infrastructure that provides the biomedical research community with the tools needed to unravel the role of gene function in human disease.

General information collated to help with the implementation of approaches to reduce and refine the use of GA mice.

A key aim of the Group is to encourage people to take account of the whole lifetime experience of laboratory rodents, ensuring that every potential impact on their wellbeing has been reviewed and refined.