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Over the last two years, representatives from the UK’s stroke research community have been working, in a collaboration led by the NC3Rs, to improve the welfare and increase the scientific value of rodent models of stroke. The findings from the collaboration - The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments) have been published in the Journal of Cerebral Bloodflow and Metabolism.
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Over the past twenty years or so, there has been a ‘revolution’ in the life sciences,and our knowledge and capabilities have dramatically increased. At the same time, these advances have raised very important ethical concerns in both the scientific community and with the public at large.