FRAME is dedicated to the development of new and valid methods that will replace the need for laboratory animals in medical and scientific research, education, and testing. Where the use of animals is currently necessary, FRAME supports the reduction of numbers involved to an unavoidable minimum and refinement of experimental procedures to minimise any suffering caused. The E-learning resource of FRAME has been set up to provide teachers, school children, students and general supporters with information about the different areas of animal experimentation and with specific resources as to how it can be reduced, refined or replaced. 

3rs-Reduction is a new interactive web-site designed to help scientists to improve the design of their animal experiments. Animal experiments are not always well designed, leading to both ethical concerns and a waste of scientific resources. This is a world-wide problem. Training scientists is difficult as there so are few statisticians with a good understanding of laboratory animal science able to provide such training. This new web-site is designed to help scientists to teach themselves the necessary skills. After an introduction on the ethics of animal experimentation, showing that improvements are needed, it goes on to  cover choice of experimental units, avoiding bias, power and sample size, controlling variability, types of experimental design, factorial experiments, statistical analysis and publication guidelines. Most sections are followed by a "Test yourself" page of true/false questions. The web-site is free. 

Humane Endpoints Website is provided by 3Rs-Centre Utrecht Life Sciences, gives insight into the recognition and application of humane endpoints in rodents. The website contributes to refinement, the prevention of unnecessary suffering in laboratory animals, by offering information, videos and photographs of rodent species. In addition, the website provides free training modules (accessible after registration). The site is currently available in EN, NL and FR. DE and ES will follow soon.

The aim of "InVitroJobs" is to enable researchers to access this branch of research more easily. Alongside the job search portal, the site maintains an up-to-date list of research groups active in the development of animal-free techniques. The primary aims of this list are to advertise job vacancies, to provide students with the opportunity to contact these research groups directly to obtain information for thesis assignments and to promote cooperation, networking and the exchange of ideas between researchers. 

A mainly government funded body which provides input to the UK’s Three Rs agenda, carries out research and provides funds for Three R research.