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The Foundation for Liver Research UK was established in 1974 to develop and extend research into diseases of the human liver and to enhance medical research generally.

CLDF supports a wide range of projects, including clinical and laboratory-based research, lately moving into social research which looks at topics such as how to improve quality of life. 

Over the last two years, representatives from the UK’s stroke research community have been working, in a collaboration led by the NC3Rs, to improve the welfare and increase the scientific value of rodent models of stroke. The findings from the collaboration - The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)  have been published in the Journal of Cerebral Bloodflow and Metabolism.

Laboratory Animals is an international journal of laboratory animal science and welfare. Laboratory Animals publishes peer-reviewed original papers and reviews on all aspects of the use of animals in biomedical research. The journal promotes improvements in the welfare or well-being of the animals used, it particularly focuses on research that reduces the number of animals used or which replaces animal models with in vitro alternatives.

Laboratory Animals publishes papers dealing with all aspects of the use of animals in biomedical research, including: new animal models; laboratory animal microbiology; clinical case reports; descriptions of new or improved research techniques; reports on the influence of environmental and other variables on research results; descriptions of techniques which offer replacements for in vivo models; and basic data characterizing the haematology, biochemistry or pathology of new or existing animal models. Papers describing work which involves a reduction in the number of animals that need to be used; or which replace animals with in vitro alternatives; or which represent a significant refinement in methodology, leading to improvements in the welfare or wellbeing of the animals used, are especially encouraged.

Journal of Applied Animal Welfare Science (JAAWS) is a US journal that publishes articles, commentaries, and brief research reports on methods of experimentation, husbandry and care that demonstrably enhance the welfare of all nonhuman animals.