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The OIE is the intergovernmental organisation responsible for improving animal health worldwide.
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CCAC promotes the application of Three Rs in Canada. Through a website it provides the latest information on the Three Rs, a search tool and a search guide.
FRAME is dedicated to the development of new and valid methods that will replace the need for laboratory animals in medical and scientific research, education, and testing. Where the use of animals is currently necessary, FRAME supports the reduction of numbers involved to an unavoidable minimum and refinement of experimental procedures to minimise any suffering caused. The E-learning resource of FRAME has been set up to provide teachers, school children, students and general supporters with information about the different areas of animal experimentation and with specific resources as to how it can be reduced, refined or replaced.