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3Rs

The Design of Animal Experiments

"The Design of Animal Experiments" is intended for all research scientists who use laboratory animals, with the aim of helping them to design their own experiments more effectively.

Topic: Reduction

Isogenic Strains

Isogenic strains (inbred strains and F1 hybrids) are like immortal clones of genetically identical individuals. The same genotype can be reproduced indefinitely. They have already made a substantial contribution to biomedical research. 

Topic: Reduction

Reducing Mouse Numbers by Measuring Tumour Size Non-Invasively

Scientists at the ICR are increasingly using non-invasive methods to measure the size of tumours in mice – allowing the same mouse to be assessed several times and reducing the overall numbers

Topic: Reduction

SABRE Research UK

Systematic reviews: Evidence from animal research is considered by researchers to be of the lowest quality in medical research.

Topic: Reduction

Ex Vivo Culture Platform for Assessment of Cartilage Repair Treatment Strategies

There is a great need for valuable ex vivo models that allow for assessment of cartilage repair strategies to reduce the high number of animal experiments.

Topic: Reduction

General Database Information

CELPHEDIA (Creation, Breeding, Phenotyping, Distribution and Archiving of Model Organisms)

CELPHEDIA (Creation, Breeding, Phenotyping, Distribution and Archiving of model organisms) is a national operational research infrastructure distributed over the French territory. Its mission is to support academic and industrial scientific community to accelerate discoveries in biology and improve biomedical research.

Topic: Information on drugs and diseases

European Pharmaceutical Market Research Association (EphMRA)
Topic: Information on drugs and diseases

EURL ECVAM

The EURL ECVAM DataBase service on ALternative Methods (DB-ALM).

Topic: Alternative methods, Information on drugs and diseases

Toxicology Data Network

Toxicology Data Network- is a group of databases covering chemicals and drugs, diseases and the environment, environmental health, occupational safety and health, poisoning, risk assessment and regulations, and toxicology.

Topic: Information on drugs and diseases

CAMARADES

The CAMARADES collaboration provides a supporting framework for groups involved in the systematic review and meta-analysis of data from experimental animal studies. 

Our interests range from identifying potential sources of bias in animal work; developing recommendations for improvements in the design and reporting of animal studies; developing the meta-analysis methodology the better to apply it to animal studies; through to the selection of candidate stroke drugs for clinical trial. 

CAMARADES aims to provide a central focus for data sharing; to act as a resource for those wishing to carry out such reviews; to provide a web based stratified meta-analysis bioinformatics engine (under development!); and to act as a repository for completed reviews.

Topic: Other Resources

International Society for Pharmacoepidemiology (ISPE)
Topic: Information on drugs and diseases

NORINA (A Norwegian Inventory of Alternatives)

NORINA is an English-language database containing information on over 3,500 audiovisual aids that may be used as alternatives or supplements to the use of animals in education and training, including dissection alternatives, at all levels from Junior School to University.  The information in the database has been collected from 1991 onwards.

Topic: Alternative methods, Search tools and databases

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