Over the last two years, representatives from the UK’s stroke research community have been working, in a collaboration led by the NC3Rs, to improve the welfare and increase the scientific value of rodent models of stroke. The findings from the collaboration - The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments) have been published in the Journal of Cerebral Bloodflow and Metabolism.
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Discipline tool
IMPROVE-ing Animal Welfare in Experimental Stroke Research
Topic: Cardiology
Jax Phenotype-Cardiovascular
Topic: Cardiology
Liverpool University Vetschool Cardiology Department
Topic: Cardiology
Penn Vet School Cardiology Research
Topic: Cardiology
Journal of Veterinary Cardiology
Topic: Cardiology
Animal Research in Pediatric Cardiology and Cardiac Surgery Paper and Pediatric Journal
Topic: Cardiology
JACC: Cardiovascular Interventions Open Access Journal
Topic: Cardiology
General Database Information
EURL ECVAM
The EURL ECVAM DataBase service on ALternative Methods (DB-ALM).
Topic: Alternative methods, Information on drugs and diseases
ARRIVE Guidelines
ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are intended to improve the reporting of research using animals – maximising information published and minimising unnecessary studies.
Topic: Other Resources
NORINA (A Norwegian Inventory of Alternatives)
NORINA is an English-language database containing information on over 3,500 audiovisual aids that may be used as alternatives or supplements to the use of animals in education and training, including dissection alternatives, at all levels from Junior School to University. The information in the database has been collected from 1991 onwards.
Topic: Alternative methods, Search tools and databases
ECVAM QSAR Model Inventory
EURL ECVAM QSAR Model Inventory of the Commission’s Joint Research Centre (JRC).
Topic: Alternative methods
CAMARADES
The CAMARADES collaboration provides a supporting framework for groups involved in the systematic review and meta-analysis of data from experimental animal studies.
Our interests range from identifying potential sources of bias in animal work; developing recommendations for improvements in the design and reporting of animal studies; developing the meta-analysis methodology the better to apply it to animal studies; through to the selection of candidate stroke drugs for clinical trial.
CAMARADES aims to provide a central focus for data sharing; to act as a resource for those wishing to carry out such reviews; to provide a web based stratified meta-analysis bioinformatics engine (under development!); and to act as a repository for completed reviews.
Topic: Other Resources