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The Allen Brain Observatory presents the first standardized in vivo survey of physiological activity in the mouse visual cortex, featuring representations of visually evoked calcium responses from GCaMP6-expressing neurons in selected cortical layers, visual areas and Cre lines. 

ATLA is published by  FRAME, and has been a key scientific journal in the field of laboratory animal alternatives for more than 30 years. Circulated worldwide, ATLA is distributed to individuals, organisations and institutions. It covers the  latest research relating to alternatives to the use of laboratory animals.

Modern human-relevant technology has the potential to provide answers traditionally sought through animal research. Yet in many of these areas there is little momentum to transition away from animal use. Education is a key driver that helps increase the impetus for change.

Replacing Animal Research believes that a whole system approach to replacing animals in research is the best way to facilitate change and ensure the development and uptake of human-relevant research methods. This system is driven by the work and choices made by various stakeholders including funders, journal editors, regulators, industry, academics, legislators, and of course scientists. Relevant training and awareness of the current research landscape are important in these roles to help inform valid scientific and ethical choices, and help prioritise non-animal research.. Through education it is possible to share information about the system, develop confidence in the use of alternative methods, and challenge the use of animals in different areas of research and testing.

The Canadian Centre for Alternatives to Animal Methods (CCAAM) and the Canadian Centre for the Validation of Alternative Methods (CaCVAM) aim to develop, validate, and promote non-animal, human biology-based platforms in biomedical research, education, and chemical safety testing.

Articles on the use of animals in research and teaching are featured on this site.