3Rs - search page

Embase is a crucial resource for discovering biomedical evidence within published, peer-reviewed literature, in-press publications and conference abstracts.

CAAT is an academic, science based centre within the John Hopkins Bloomberg School of Public Health in the USA and the University of Konstanz in Germany which is  dedicated to the promotion of research intoin vitro and other alternative techniques, Three Rs education and information.

Researchers can apply for access to data from health registries and health studies, as well as biological material from the biobanks. Here you will find guidelines and electronic application forms.

CCAC promotes the application of Three Rs in Canada. Through a website it provides the latest information on the Three Rs,   a search tool and a search guide. 

NorPEN is a network of researchers with the purpose of facilitating research within the field of pharmacoepidemiology in the Nordic countries. The website

Animal Research Info-is an international collaboration of scientists and researchers. As expert contributors, we provide and edit the content, making it as accurate and up-to-date as possible.

FRAME is dedicated to the development of new and valid methods that will replace the need for laboratory animals in medical and scientific research, education, and testing. Where the use of animals is currently necessary, FRAME supports the reduction of numbers involved to an unavoidable minimum and refinement of experimental procedures to minimise any suffering caused. The E-learning resource of FRAME has been set up to provide teachers, school children, students and general supporters with information about the different areas of animal experimentation and with specific resources as to how it can be reduced, refined or replaced. 

UMC regularly publishes scientific papers in a range of international journals. These papers record progress and results from research into clinical or methodological issues in pharmacovigilance.

The European Medicines Agency (EMA) is a decentralised agency of the European Union (EU), located in London. It began operating in 1995. The Agency is responsible for the scientific evaluation, supervision and safety monitoring of medicines developed by pharmaceutical companies for use in the EU.

Humane Endpoints Website is provided by 3Rs-Centre Utrecht Life Sciences, gives insight into the recognition and application of humane endpoints in rodents. The website contributes to refinement, the prevention of unnecessary suffering in laboratory animals, by offering information, videos and photographs of rodent species. In addition, the website provides free training modules (accessible after registration). The site is currently available in EN, NL and FR. DE and ES will follow soon.

The MRC ethics series document ‘Good research practice: principles and guidelines’ sets out the MRC’s expectations for MRC research units and institutes, MRC university units, MRC centres and MRC grant holders in the form of principles, guidelines and standards to foster good research practice in all MRC-funded research.