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Newsletter

October 2020

 
 
 



Re-starting mouse breeding after lockdown?

Increasing numbers of researchers are returning to their animal work following the COVID-19 lockdown. Many are faced with the challenge of needing to rapidly breed experimental cohorts from reduced stock or to finish experiments started prior to lockdown. Working with an expert group of researchers and colony managers, we have produced guidance on how to re-commence experiments after a pause with an emphasis on minimising the number of mice used.

Learn more

 

Breeding and colony management




Apply for funding to adopt or share a 3Rs approach

Our Skills and Knowledge Transfer scheme funds collaborations to transfer 3Rs tools, models and methods between research establishments so their 3Rs impacts can be maximised. This year it is evolving to facilitate greater connectivity between academics and industry, with SMEs now eligible to apply as the lead applicant (either the adopter or the developer of the method). Please note a Je-S account will be required to apply.

Informal outline submission is now open – the deadline to submit is 4pm (GMT) on Friday 27 November.

Learn more

If you are interested in applying for this year’s scheme, register for our webinar at 2pm on Tuesday 27 October (GMT), which will provide further details on making a competitive application.

Register now




NC3Rs collaboration leads to reduction in animal use for regulatory fish bioconcentration testing

Recommendations from an industry project led by the NC3Rs have been incorporated into guidance published by the US Environmental Protection Agency (EPA). The guidance relates to the use of fish in bioconcentration factor studies, which analyse the potential for waterborne pollutants to accumulate in fish and enter the food chain. The EPA estimates that this policy change will reduce fish use by one-third – around 240 animals per year.

Learn more

 

Fish bioaccumulation studies

 

3 Minute 3Rs podcastLatest news from the NC3Rs



Apply to solve one of this year’s CRACK IT Challenges

CRACK IT Challenges 2020

Up to £3.5 million funding is available to UK and EU-based applicants to solve five Challenges that focus on delivering 3Rs, business and scientific impacts across diverse areas:

The closing date to apply is Thursday 5 November for Two Phase Challenges and Thursday 12 November for Single Phase Challenges.

Learn more

 



Help us fund the best 3Rs research – join an NC3Rs Funding Panel

Our Funding Panels are responsible for assessing the scientific excellence and 3Rs impact of diverse, innovative applications for research and career development funding. We are currently inviting applications from senior scientists to join our Grant Assessment Panel, Studentship Assessment Panel, and Training Fellowship Assessment Panel from January 2021.

The deadline for applications is 4pm (GMT) on Tuesday 17 November.

Learn more

 

Funding Panel vacancies

 
 



Register now: 2020 Primate Welfare Meeting

Wednesday 18 November, 3-4.30pm (GMT)

This year’s Primate Welfare Meeting will take place online and will focus on sharing the findings of two international surveys on behavioural management of non-human primates and on welfare indicators for macaques and marmosets. Registration is now open to laboratory personnel working directly with non-human primates.

Register now

 

Primate Welfare Meeting 2020




Register now: Organ-on-a-chip technology - from a scientific and 3Rs perspective

Tuesday 20 October, 11am-12pm (BST)

This webinar will showcase some of the organ-on-a-chip research we have funded through our CRACK IT and research funding programmes. Dr Jos Joore (CEO and co-founder, MIMETAS) and Professor Julien Gautrot (Professor in Biomaterials and Biointerfaces, Queen Mary University of London) will give insights into their research, highlighting the scientific and 3Rs benefits of using organ-on-a-chip technology.

Register now

 

Organ-on-a-chip technology




The NC3Rs at the 71st AALAS National Meeting

This year's AALAS (American Association for Laboratory Animal Science) National Meeting will be taking place virtually – registered delegates can stream talks from 25 October to 31 December. The NC3Rs is co-sponsoring a session with Charles River Laboratories on research animal behavioural management, as well as participating in a session on best practices for inflammation-based animal models.

Learn more

 

AALAS




Recordings: The 3Rs across Europe webinar series

Europe is home to a vibrant 3Rs community with a range of organisations who fund or promote science and technology developments that lead to opportunities to replace, reduce and refine the use of animals in research. To celebrate the 3Rs in Europe, six organisations came together in September 2020 to organise a virtual event highlighting the latest 3Rs advances over three days of talks. Recordings of each talk are now available to watch online.

Watch the talks

 

The 3Rs across Europe

 
 
 
 
 



Explore fetal calf serum-free media for your next experiment

Fetal calf serum (FCS) is widely used in research, but it presents both scientific and ethical limitations. The FCS-Free Database was set up by the 3Rs-Centre ULS to provide information on FCS-free media. The database has recently been updated and now contains 630 media for 275 cell types, as well as resources to help you switch to FCS-free media.

Explore the database

 

Exploring alternatives to fetal calf serum


 
 
 
 

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NC3Rs logo

Newsletter

September 2020

 
 
 



Register now for our webinar series celebrating the 3Rs across Europe

Register now for our webinar series celebrating the 3Rs across Europe



Europe is home to a vibrant 3Rs community with a range of organisations who fund or promote science and technology developments that lead to opportunities to replace, reduce and refine the use of animals in research. Many of these developments also lead to the generation of new scientific knowledge that has benefits for human and animal health and the protection of the environment.

To celebrate the 3Rs in Europe, six organisations have come together to organise a virtual event to highlight the latest 3Rs opportunities. The event will be held over three days from 22 to 24 September with presentations from two nominated speakers from each of the organisations. Researchers at all career stages who use animals or are interested in how they can help support the 3Rs are encouraged to participate.

Learn more and register




Join the NC3Rs Board and help shape our strategy

We are seeking up to four new members to join our Board from 1 January 2021. Our Board supports our work by advising us on strategy and monitoring our use of resources and the delivery of our work plan. If you are a senior scientist in academia or industry, or a senior manager or veterinarian in a laboratory animal facility, we would like to hear from you.

The deadline for applications is 4pm on Wednesday 7 October. Interviews will be held on Tuesday 10 November.

Learn more

 

Board Chair recruitment




Vacancy: Science Manager – Innovation

We are seeking a Science Manager to join the NC3Rs team and support our CRACK IT Open Innovation Programme. Applicants should have a PhD in a biological science, demonstrable commitment to the 3Rs and the ability to work as part of a dynamic team.

The closing date for applications is Sunday 4 October.

Learn more and apply

 

Join the NC3Rs team




Tunnel handling improves the welfare of mice undergoing repeated procedures

New research published in Scientific Reports has shown that the animal welfare benefits of picking up laboratory mice via a tunnel instead of by the tail persist even after repeated restraint, intraperitoneal injection and anaesthesia. The work, led by Dr Lindsay Henderson at Newcastle University, adds to the substantial evidence supporting tunnel handling as a way to reduce handling-related stress, even when experimental protocols require the use of more aversive procedures.

Learn more

 

Tunnel handling improves the welfare of mice undergoing repeated procedures




Listen to the 3 Minute 3Rs podcast

Every month, 3 Minute 3Rs provides a recap of the latest 3Rs research papers, chosen by Lab Animal, the North American 3Rs Collaborative and the NC3Rs. Our most recent episode featured papers on ARRIVE 2.0, stress-induced analgesia in zebrafish and an optimised olfactory test. Listen now or subscribe wherever you get your podcasts.

Listen or subscribe now

 

3 Minute 3Rs podcast

 



Apply for this year’s CRACK IT Challenges

CRACK IT Challenges 2020

The 2020 CRACK IT Challenges competition is now open. Up to £3.5 million funding is available to UK and EU-based applicants to solve five Challenges that focus on delivering 3Rs, business and scientific impacts across diverse areas including wound healing, mouse welfare, animal-free reagents and in vitro immunology. This year’s Challenges are supported by 11 Sponsors from across the academic, public, pharmaceutical and fast-moving consumer goods sectors, with co-funding from Dstl, EPSRC and Unilever to support specific Challenges.

Learn more and apply

 

Latest news from the NC3RsReturning to research: is there an opportunity for you to adopt a 3Rs approach?

  • Do you want to adopt a new in vitro, ex vivo or in silico model?
  • Is there an approach you could adopt to maximise data using fewer animals?
  • Are you interested in funding to help you adopt or transfer a method to a new collaborator and fully realise the impact of your work?

Apply for an NC3Rs Skills and Knowledge Transfer Award

  • Awards are for up to 24 months
  • Maximum of £75k funding (80% FEC)
  • Apply as either the adopter or the developer of the method
  • Informal outline submission is now open – deadline 4pm on Sunday 27 November

Learn more and apply




£2.4 million awarded to support the development of new 3Rs approaches

Our flagship project grant scheme has been running since the NC3Rs' conception in 2004. Following seven new awards, we have now committed over £40m to the development of 3Rs approaches and technologies with lasting 3Rs legacies. This year’s awards include three projects focusing on applying the 3Rs to various aspects of veterinary research.

Learn more

 

Colourful test tubes

 
 

Webinars



Register now: 2020 Primate Welfare Meeting

Wednesday 18 November, 3-4.30pm (GMT)

This year’s Primate Welfare Meeting will take place online and will focus on sharing the findings of two international surveys on behavioural management of non-human primates and on welfare indicators for macaques and marmosets. Registration is now open to laboratory personnel working directly with non-human primates.

Learn more and register

 

Primate Welfare Meeting 2020




Recording: Compassion fatigue in laboratory animal research

Many laboratory animal technicians enter this profession because they love animals, but this caring role may come at a cost to their own wellbeing. We recently held a joint webinar with the North American 3Rs Collaborative (NA3RsC), presented by NA3RsC Fellow Dr Megan LaFollette, focusing on compassion fatigue and the effect it can have on animal care staff.

Watch the recording

 

Compassion fatigue webinar




Recording: The ARRIVE guidelines 2.0

If you are interested in producing reliable and reproducible research, the revised ARRIVE guidelines will help you ensure you report the most critical information. Watch the recording of our ARRIVE 2.0 webinar to find out more about resources to support use of the guidelines and the importance of the “Essential 10” pieces of information.

Watch the recording

 

ARRIVE guidelines 2.0

 
 



What could an NC3Rs Training Fellowship do for you?

Our Training Fellowship scheme supports promising early career researchers to develop new skills and gain a breadth of research experience, preparing them for an independent career in academia. We recently spoke to Dr Deepali Pal, who has just completed her Training Fellowship, to find out how being an NC3Rs Fellow has helped advance her career.

Read the blog post

 

Deepali Pal

 
 



Event: Advances in Cell and Tissue Culture Conference (ACTC 2020)

ACTC 2020 will take place over two days on Wednesday 30 September and Thursday 1 October as a virtual event. It will bring together industry and academic researchers working in all areas of in vitro cell culture to exchange knowledge, promote their activities and set up new collaborative projects. Topics covered will include advanced skin and respiratory models, novel models for studying neurological diseases and in vitro models for animal replacement.

Learn more and register

 

ACTC 2020